Lipase-catalyzed preparation of optically active 1′-acetoxychavicol acetates and their structure–activity relationships in apoptotic activity against human leukemia HL …

…, T Tachibana, A Kojima-Yuasa, I Matsui-Yuasa…

Index: Azuma, Hideki; Miyasaka, Keita; Yokotani, Tsuyoshi; Tachibana, Taro; Kojima-Yuasa, Akiko; Matsui-Yuasa, Isao; Ogino, Kenji Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1811 - 1818

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Citation Number: 22

Abstract

Structure–activity relationships of 1′-acetoxychavicol acetate (ACA) for apoptotic activity against human leukemia HL-60 cells were investigated using optically active ACA and various racemic ACA analogues. Natural-type (or with different acyl group) ACA showed a high apoptotic activity, but the ortho or meta isomers, 4-deacetoxy analogue, and the 2′– 3′ dehydrogenated derivative had no effect, or a weak activity. Optically active (R)-and (S ...