We synthesized new cationic lipids, analogue to N-[1-(2, 3-dioleoyloxy) propyl]-N, N, N- trimethylammonium chloride (DOTMA) and 1, 2-dimyristyloxypropyl-3-dimethyl- hydroxyethylammonium bromide (DMRIE), in order to compare those containing a dodecyl chain with those having a relatively long chain with two or five double bonds, such as squalenyl and dihydrofarnesyl derivatives, or complex saturated structures, such as ...