Il Farmaco

Synthesis, characterization and transfection activity of new saturated and unsaturated cationic lipids

S Arpicco, S Canevari, M Ceruti, E Galmozzi, F Rocco…

Index: Arpicco, Silvia; Canevari, Silvana; Ceruti, Maurizio; Galmozzi, Enrico; Rocco, Flavio; Cattel, Luigi Farmaco, 2004 , vol. 59, # 11 p. 869 - 878

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Citation Number: 35

Abstract

We synthesized new cationic lipids, analogue to N-[1-(2, 3-dioleoyloxy) propyl]-N, N, N- trimethylammonium chloride (DOTMA) and 1, 2-dimyristyloxypropyl-3-dimethyl- hydroxyethylammonium bromide (DMRIE), in order to compare those containing a dodecyl chain with those having a relatively long chain with two or five double bonds, such as squalenyl and dihydrofarnesyl derivatives, or complex saturated structures, such as ...