Growth inhibition and induction of cellular differentiation of human myeloid leukemia cells in culture by carbamoyl congeners of ribavirin

…, BK Bhattacharya, GD Kini, SS Matsumoto…

Index: Sanghvi, Yogesh S.; Bhattacharya, Birendra K.; Kini, Ganesh D.; Matsumoto, Steven S.; Larson, Steven B.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 336 - 344

Full Text: HTML

Citation Number: 87

Abstract

A series of 1, 2, 3-triazole (2), pyrazole (3 and 5), and pyrrole (4) ribonucleosides with two adjacent carbamoyl groups have been synthesized and evaluated for cell growth inhibition and induction of cellular differentiation of HL-60 cells in culture. Glycosylation of the TMS derivatives of dimethyl 1, 2, 3-triazole-4, 5-dicarboxylate(6) and diethyl pyrazole-3, 4- dicarboxylate (7) with 1-0-acetyl-2, 3, 5-tri-O-benzoyl-~-ribofuranose (8) in the presence of ...