1-(5'-Fluoro-6'-hydroxy-5', 6'-dihydrouracil-5'-yl)-5-fluorouracil, a novel N (1)-C (5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic …

S Nishimoto, H Hatta, H Ueshima…

Index: Nishimoto; Hatta; Ueshima; Kagiya Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2711 - 2712

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Citation Number: 34

Abstract

1- (5'-Fluoro-6/-hydroxy-S/,6/-dihydrouracil-5~-yl)-5- fluorouracil, a Novel N( l)-C(S)-Linked Dimer That Releases 6-Fluorouracil by Radiation Activation under Hypoxic Conditions ... One of the strategies for reducing local failure in ra- diotherapy of tumors is the use of chemical agents which increase the killing or growth inhibitory effect on hypoxic tumor cells in conjunction with irradiation. Major atten- tion has been hitherto paid to electron-affmic radiosen- sitizere ...