Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1

…, M Miyakawa, JR Bunzow, DK Grandy…

Index: Tan, Edwin S.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S. Journal of Medicinal Chemistry, 2007 , vol. 50, # 12 p. 2787 - 2798

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Citation Number: 34

Abstract

3-Iodothyronamine (1, T1AM) is a naturally occurring derivative of thyroid hormone that can potently activate the orphan G protein-coupled receptor (GPCR) known as the trace amine- associated receptor 1 (TAAR1). We have previously found that modifying the outer ring of the phenoxyphenethylamine core scaffold of 1 can improve potency and provide potent agonists. In this study, we explored the tolerance of rat and mouse TAAR1 (rTAAR1 and ...