Technetium-99m labelled integrated tropane–BAT as a potential dopamine transporter tracer

…, L Mortelmans, GM Bormans, AM Verbruggen

Index: Cleynhens, Bernard J.; De Groot, Tjibbe J.; Vanbilloen, Hubert P.; Kieffer, Davy; Mortelmans, Luc; Bormans, Guy M.; Verbruggen, Alfons M. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1053 - 1058

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Citation Number: 8

Abstract

To reduce the molecular weight of 99mTc-labelled tropanes with the aim to enhance the passage over the blood–brain barrier, a so-called integrated tropane–BAT construct was developed. For this purpose a mercaptoethyl substituent was attached to the amine nitrogen atom of a nortropane precursor and the methyl carboxylate in 2β-position was converted to a 2-mercaptoethylaminomethylene substituent. This integrated tropane–BAT construct could ...