Synlett

Direct synthesis of protected arylacetaldehydes by palladium-tetraphosphine-catalyzed arylation of ethyleneglycol vinylether

I Kondolff, H Doucet, M Santelli

Index: Kondolff, Isabelle; Doucet, Henri; Santelli, Maurice Synlett, 2004 , # 9 p. 1561 - 1564

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Citation Number: 10

Abstract

Abstract Through the use of [PdCl (C 3 H 5)] 2/cis, cis, cis-1, 2, 3, 4-tetrakis ( diphenylphosphinomethyl) cyclopentane as a catalyst, a range of aryl bromides undergo Heck reaction with ethyleneglycol vinylether to give regioselectively protected arylacetaldehydes in good yields. The β-arylation products were obtained in the range 93- 98% selectivity with electron-poor aryl bromides. Furthermore, this catalyst can be used at ...