An Improved Large-Scale Preparation of Benzimidazole-2-Sulfonic Acids and 2-Chlorobenzimidazoles.‡

…, JA Walker, EE Swayze, LB Townsend∗

Index: Hinkley, Jack M.; Porcari, Anthony R.; Walker II, John A.; Swayze, Eric E.; Townsend, Leroy B. Synthetic Communications, 1998 , vol. 28, # 9 p. 1703 - 1712

Full Text: HTML

Citation Number: 15

Abstract

Abstract An improved method for the preparation of benzimidazole-2-sulfonic acids from 2- mercaptobenzimidazoles has been developed which utilizes aqueous sodium percarbonate. 2-Chlorobenzimidazoles were obtained in high yield from the corresponding sulfonic acids upon reaction with PCl5 in POCl3 on a gram-mole scale.‡ Dedicated to Henry Koppel.