The syntheses of new γ-ethoxycarbonyl-and α-amino-alkyl hydroxymethylphosphinic acid derivatives are described. These compounds were conveniently prepared by Michael addition or Kabachnik–Fields reaction of an original precursor, ethyl benzyloxymethyl hydrogenophosphinate, respectively to α, β-unsaturated esters using a basic activation or to imines. Selective deprotection of the alcohol function was achieved by hydrogenolysis on ...
