Abstract 2-Phenylhistamines with various substituents at the phenyl ring were synthesized and the influence of substitution in ortho, meta or para position on histamine H 1-agonistic activity was investigated. Compounds with high activity occurred in the meta phenyl series. Increased activity in the guinea-pig ileum assay was achieved by monosubstitution with halogen on the phenyl ring. 2-[2-(3-Fluorophenyl)-4-imidazolyl] ethanamine (12) is the ...
![[4-(1,3-dioxoisoindol-2-yl)-2-oxobutyl] acetate Structure](https://image.chemsrc.com/caspic/025/65465-66-9.png)