Search for Highly Efficient, Stereoselective, and Practical Synthesis of Complex Organic Compounds of Medicinal Importance as Exemplified by the Synthesis of the …

…, S Xu, Q Hu, F Zeng, E Negishi

Index: Wang, Guangwei; Xu, Shiqing; Hu, Qian; Zeng, Fanxing; Negishi, Ei-Ichi Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 12938 - 12942

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Abstract

As the ability of the synthetic community to assemble a wide variety of highly complex natural products and related compounds of biological and medicinal importance increases, what is becoming increasingly desirable is the development of “ultimately” satisfactory and potentially practical multistep syntheses. Since linear reaction series of 20, 25, and 30 steps of 90% yield each lead to overall yields of only 12, 7, and 4%, respectively, it would ...