Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2-or 6-acyl-5, 8-dimethoxy-1, 4-naphthoquinones

…, Y Kim, XG Zheng, YJ You, H Cho, JH Chung…

Index: Song, Gyu-Yong; Kim, Yong; Zheng, Xiang-Guo; You, Young-Jae; Cho, Hoon; Chung, Jin-Ho; Sok, Dai-Eun; Ahn, Byung-Zun European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 291 - 298

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Citation Number: 40

Abstract

Some 2-or 6-acyl-5, 8-dimethoxy-1, 4-naphthoquinone (DMNQ) derivatives were synthesized and evaluated for inhibition of DNA topoisomerase I and cytotoxicity against L1210 cells. Compared with 2-acyl-DMNQ derivatives, 6-acyl-DMNQ compounds, bearing a higher electrophilic quinone moiety, showed a higher potency in the inhibition of DNA topoisomerase I and the cytotoxicity, implying the possible participation of electrophilic ...