Tetrahedron

Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: effect of substrate structure and mechanism

B Baskar, NG Pandian, K Priya, A Chadha

Index: Baskar; Pandian; Priya; Chadha, Anju Tetrahedron, 2005 , vol. 61, # 52 p. 12296 - 12306

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Citation Number: 46

Abstract

Candida parapsilosis ATCC 7330 was found to be an efficient biocatalyst for the deracemisation of aryl α-hydroxy esters (65–85% yield and 90–99% ee). A variety of aryl and aryl substituted α-hydroxy esters were synthesized to reflect steric and electronic effects on biocatalytic deracemisation. The mechanism of this biocatalytic deracemisation was found to be stereoinversion.