Synthesis of Some New S??Alkylated 1, 2, 4??Triazoles, Their Mannich Bases and Their Biological Activities

MM Alam, S Nazreen, S Haider, S Shafi…

Index: Alam, Mohammad Mahboob; Nazreen, Syed; Haider, Saqlain; Shafi, Syed; Yar, Mohammad Shahar; Hamid, Hinna; Alam, Mohammad Sarwar Archiv der Pharmazie, 2012 , vol. 345, # 3 p. 203 - 214

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Citation Number: 10

Abstract

Abstract A series of 1-(4-methoxyphenyl)-2-[5-{(biphenyl-4-yloxy) methyl} 4-(substituted phenyl)-3-mercapto-(4H)-1, 2, 4-triazol-3-ylthio)] ethanones (6a–6s) and 4-(substituted phenyl)-3-(morpholin/pyrrolidin-4-ylmethylthio)-5-(4-phenylphenoxymethyl)-4H-1, 2, 4- triazoles (7a–7e) were synthesized in order to obtain new compounds with potent anti- inflammatory and analgesic activity with insignificant ulceration. Among the synthesized ...