Tetrahedron letters

Facile synthesis of silyl enol ethers by Mg-promoted coupling of aliphatic carbonyl compounds with trimethylsilyl chloride

…, Y Kita, H Maekawa, T Ohno, Y Yamasaki, T Miyata…

Index: Ishino, Yoshio; Kita, Yoshio; Maekawa, Hirofumi; Ohno, Toshinobu; Yamasaki, Yasuhiro; Miyata, Toshiyuki; Nishiguchi, Ikuzo Tetrahedron Letters, 1999 , vol. 40, # 7 p. 1349 - 1352

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Citation Number: 17

Abstract

Treatment of aliphatic carbonyl compounds with trimethylsilyl chloride with Mg turning for Grignard reaction without any pre-treatment in N, N-dimethylformamide at room temperature brought about highly facile, effective and stereoselective coupling to give the corresponding silyl enol ethers in good yields.