Inotropic activity of heterocyclic analogues of isomazole

…, RM Beams, JW Black, D Cambridge, D Collard…

Index: Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477

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Citation Number: 16

Abstract

Abstract Aryl-substituted benzimidazole, imidazopyridine, imidazopyrazine, imidazopyridazine, oxazolopyridine, purine, pyrollopyridine and thiazolopyridine derivatives have been prepared and evaluated as inotropic agents. Purine 8 and the 1H-imidazo [4, 5-c]- and [4, 5-d] pyridazines 9 and 10 proved to be of most interest, having similar in vivo inotropic potencies to sulmazole. The pKa's, protonation sites and lipophilicities for most ...