Synthesis of Some N 4-Substituted Derivatives of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy) propyl] cytosine (HPMPC, Cidofovir)

…, A Holý, M Masojídková

Index: Chalupova, Sarka; Holy, Antonin; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 12 p. 2053 - 2065

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Citation Number: 5

Abstract

Abstract N 4-Substituted derivatives of HPMPC were synthesized in four-step synthesis which included treatment of 4-methoxypyrimidin-2 (1H)-one (1) with (S)-[(trityloxy) methyl] oxirane in DMF. Condensation of intermediary 1-[2-hydroxy-3-(trityloxy) propyl]-4- methoxypyrimidin-2 (1H)-one (2) with (diisopropoxyphosphoryl) methyl tosylate in the presence of sodium hydride resulted in fully protected 4-methoxypyrimidin-2 (1H)-one ...