Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines

H Ouyang, SL Morris-Natschke, KS Ishaq…

Index: Ouyang, Hui; Morris-Natschke, Susan L.; Ishaq, Khalid S.; Ward, Peter; Liu, Dongzhou; Leonard, Sarah; Thakker, Dhiren R. Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2857 - 2866

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Citation Number: 18

Abstract

Paracellular permeability enhancers have been used to improve the oral bioavailability of hydrophilic drugs; however, the mechanism of action of many enhancers is poorly understood. In this study, highly potent enhancers of paracellular permeability were identified in the 3-alkylamido-2-alkoxypropylphosphocholine series, and a structure-activity relationship was developed for enhancement of paracellular permeability across Caco-2 ...