Chemistry–A European Journal

Iridium??Catalyzed Coupling Reaction of Primary Alcohols with 2??Alkynes Leading to Hydroacylation Products

S Hatanaka, Y Obora, Y Ishii

Index: Hatanaka, Shintaro; Obora, Yasushi; Ishii, Yasutaka Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1883 - 1888

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Citation Number: 30

Abstract

Abstract A novel iridium-catalyzed intermolecular coupling reaction of primary alcohols or aldehydes with 2-alkynes was successfully achieved with high regioselectivity to give hydroacylation products such as α, β-unsaturated ketones in good yields. The mechanistic investigation of the reaction strongly indicated that the coupling proceeds through the initial formation of homoallylic alcohols followed by dehydrogenation to β, γ-unsatutated ketones ...