Synthesis of a new series of pyrazolo [1, 5??a] pyrimidines structurally related to zaleplon

…, E Ongini, H El??Kashef, MD Carrion…

Index: Baraldi, Pier Giovanni; Fruttarolo, Francesca; Tabrizi, Mojgan Aghazadeh; Romagnoli, Romeo; Preti, Delia; Ongini, Ennio; El-Kashef, Hussein; Carrion, Maria Dora; Borea, Pier Andrea Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 2 p. 355 - 361

Full Text: HTML

Citation Number: 14

Abstract

In the last decade, the treatment of insomnia has been supplemented by the introduction of a number of nonbenzodiazepine hypnotics including zolpidem, zopiclone and, most recently, zaleplon [1-4]. Zaleplon (N-[3-(cyanopyrazolo [1, 5-a] pyrimidin-7-yl)-phenyl]-N- ethylacetamide, 1a, Figure 1) is a new pyrazolopyrimidine hypnotic that selectively binds to the α1-GABAA receptor subunit, enhancing the function of GABA as a result of an ...