Tetrahedron Letters

Synthesis of 2-chloro-5, 7-dihydro-6H-pyrrolo [2, 3-d] pyrimidin-6-one

M Cheung, PA Harris, KE Lackey

Index: Cheung, Mui; Harris, Philip A.; Lackey, Karen E Tetrahedron Letters, 2001 , vol. 42, # 6 p. 999 - 1001

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Citation Number: 13

Abstract

1, 3-Dihydro-2H-indol-2-ones (oxindoles) and 1, 3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5, 7-dihydro-6H-pyrrolo [2, 3-d] pyrimidin-6- one (5) and its derivatives, and the application of 5, 7-dihydro-6H-pyrrolo [2, 3-d] pyrimidin-6- ones (diazaoxindoles) as novel scaffold to kinase research areas.