Lipase Active??Site??Directed Anchoring of Organometallics: Metallopincer/Protein Hybrids

…, MR Egmond, A van der Kerk??van Hoof…

Index: Kruithof, Cornells A.; Casado, Miguel A.; Guillena, Gabriela; Egmond, Maarten R.; Van Der Kerk-van Hoof, Anca; Heck, Albert J.R.; Gebbink, Robertas J.M. Klein; Van Koten, Gerard Chemistry - A European Journal, 2005 , vol. 11, # 23 p. 6869 - 6877

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Citation Number: 78

Abstract

Abstract The work described herein presents a strategy for the regioselective introduction of organometallic complexes into the active site of the lipase cutinase. Nitrophenol phosphonate esters, well known for their lipase inhibitory activity, are used as anchor functionalities and were found to be ideal tools to develop a single-site-directed immobilization method. A small series of phosphonate esters, covalently attached to ECE “ ...