Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)

SH Kim, AT Pudzianowski, KJ Leavitt, J Barbosa…

Index: Kim, Soong-Hoon; Pudzianowski, Andrew T.; Leavitt, Kenneth J.; Barbosa, Joseph; McDonnell, Patricia A.; Metzler, William J.; Rankin, Bruce M.; Liu, Richard; Vaccaro, Wayne; Pitts, William Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1101 - 1106

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Citation Number: 49

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Computer aided drug design led to a new class of spiro-barbiturates (eg, 4a, MMP-13 K i = 4.7 nM) that are potent inhibitors of MMP-13. ... Osteoarthritis is a degenerative disease characterized by the loss of joint function and articular cartilage. Current therapies, such as COX-2 ...