Tetrahedron

Structure-reactivity relationships in (2-hydroxyethyl) benzophenone photoremovable protecting Groups

MC Pirrung, BG Roy, S Gadamsetty

Index: Pirrung, Michael C.; Roy, Biswajit Gopal; Gadamsetty, Surendra Tetrahedron, 2010 , vol. 66, # 17 p. 3147 - 3151

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Citation Number: 5

Abstract

A detailed study of substituent effects on the photochemical conversion of esters of (2- hydroxyethyl) benzophenone to the carboxylic acid was performed with the aim of improving on the reactivity of the parent, which was first reported decades ago. Over 20 derivatives were prepared, 10 of which exhibit some level of photochemical reactivity, but none of them is appreciably better than the original. The reaction did not respond to a thioxanthone as a ...