Studies of the selective O-alkylation and dealkylation of flavonoids. 13. An improved method for synthesizing 5, 6, 7-trihydroxyflavones from 6-hydroxy-5, 7- …

…, H Tominaga, Y Kawamura, T Yamada

Index: Horie; Tominaga; Kawamura; Yamada Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3343 - 3347

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Citation Number: 16

Abstract

The demethylation of five 6-hydroxy-5, 7-dimethoxyflavones 1 and their acetates with 30% w/v anhydrous aluminum chloride in acetonitrile waa studied, and the following results were found. In the demethylation of 6-hydroxy-4', 5, 7-trimethoxyflavone (la), 5, 6-dihydroxy-4', 7- dimethoxyflavone (2a) and 5, 6, 7-trihydroxy-4'-methoxyflavone (3a) were produced. Although the ratio of the two products varied according to the amount of aluminum ...