Synthesis of 6-(3-aryl-2-propenyl)-2, 3-dihydro-5-hydroxybenzofuran derivatives by cross coupling reactions

RJ Alabaster, IF Cottrell, D Hands, GR Humphrey…

Index: Alabaster, Ramon J.; Cottrell, Ian F.; Hands, David; Humphrey, Guy R.; Kennedy, Derek J.; et al. Synthesis, 1989 , # 8 p. 598 - 603

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Citation Number: 9

Abstract

The synthesis of 6-(3-aryl-2-propcnyl)-2, 3-dihydro-5-hydroxybenzofuran derivatives by cross coupling between 6-bromo-2, 3-dihydrobenzofurans and cinnamyl halides via organo- metallic compounds has been explored. Palladium catalysed reaction between benzofurylzinc bromides and cinnainyl acetates gave high yields of pure products, and the reaction was developed into an economic process for the large scale preparation of 2, 3- ...