Abstract The title compound, 17aβ-hydroxy-7α-methyl-d-homoestra-4, 16-dien-3-one (3), was synthesized in five steps (17% overall yield) from 7α-methylestrone methyl ether (5) and was found to possess oral androgenic activity, in excess of other known androgens, without using 17α-alkyl substitution.(Steroids 55: 59–64, 1990)
