Copper??Catalyzed Synthesis of α??Hydroxy Phosphonates from H??Phosphonates and Alcohols or Ethers

Z Zhao, W Xue, Y Gao, G Tang…

Index: Zhao, Zengxiang; Xue, Wanhua; Gao, Yuxing; Tang, Guo; Zhao, Yufen Chemistry - An Asian Journal, 2013 , vol. 8, # 4 p. 713 - 716

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Citation Number: 28

Abstract

Zengxiang Zhao,[a] Wanhua Xue,[a] Yuxing Gao,[a] Guo Tang,*[a] and Yufen Zhao [a, b] α- Hydroxy phosphonates have attracted considerable attention owing to their critical roles in anticancer drugs, plant growth regulators, and enzyme inhibitors.[1] The traditional way to synthesize α-hydroxy phosphonates is an addition reaction of monobasic phosphorus (the Pudovik reaction) or odorous trialkyl phosphite (the Abramov reaction) to an aldehyde or ...