N-Boc Deprotection and Isolation Method for Water-Soluble Zwitterionic Compounds

Z Liu, N Yasuda, M Simeone…

Index: Miller, Steven P.; Zhong, Yong-Li; Liu, Zhijian; Simeone, Michael; Yasuda, Nobuyoshi; Limanto, John; Chen, Zheng; Lynch, Joseph; Capodanno, Vincent Organic Letters, 2014 , vol. 16, # 1 p. 174 - 177

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Abstract

A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitterionic compounds from the corresponding N-Boc derivatives has been developed. This method has been demonstrated in the final deprotection/isolation of the β-lactamase