Tetrahedron Letters

Practical reduction of oxazolines to alcohols

A Bernardi, SG Ouellet, R Angelaud, PD O'Shea

Index: Bernardi, Anna; Ouellet, Stephane G.; Angelaud, Remy; O'Shea, Paul D. Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6707 - 6708

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Citation Number: 4

Abstract

A two-step, one-pot procedure using methyl chloroformate and lithium borohydride was developed to transform 2-substituted-oxazolines into alcohols. This methodology is compatible with a wide range of substrates including heterocyclic, aromatic, and aliphatic functionalized 2-oxazolines. Best results are obtained with electron-rich and ortho substituted 2-aryl-oxazolines.

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