Preparation, purification, and NMR spectra of some mono-and dihemisuccinates of the trichothecene mycotoxin nivalenol

DR Lauren, WA Smith, AL Wilkins

Index: Lauren, Denis R.; Smith, Wendy A.; Wilkins, Alistair L. Journal of Agricultural and Food Chemistry, 1994 , vol. 42, # 3 p. 828 - 833

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Citation Number: 2

Abstract

4, 15-Diacetylnivalenol (DANIV) was produced in liquid culture and purified by fractionation over silica followed by preparative liquid chromatography. Hydrolysis gave nivalenol (NIV), a trichothecene mycotoxin found as a common contaminant in grain grown in the North Island of New Zealand. Reaction of NIV with succinic anhydride in the presence of n-butylboronic acid and (dimethy1amino) pyridine produced a mixture of three mono-and two ...