Tetrahedron Letters

Improved accessibility to the desoxy analogues of Δ 9-tetrahydrocannabinol and cannabidiol

SM Wilkinson, J Price, M Kassiou

Index: Wilkinson, Shane M.; Price, Jason; Kassiou, Michael Tetrahedron Letters, 2013 , vol. 54, # 1 p. 52 - 54

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Citation Number: 4

Abstract

Desoxy analogues of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have been reported to provide a novel mode of analgesia whilst avoiding the psychotropic side effects associated with most cannabinoid drugs. A detailed and improved synthesis of desoxy THC, desoxy CBD and didesoxy CBD is reported here. The key improvements include a concentration-dependent boron trifluoride mediated electrophilic aromatic substitution ...