Doklady Chemistry

A new method for the synthesis of α-aryl-substituted pyrrolines and tetrahydropyridines

AB Koldobskii, VE Vakhmistrov, EV Solodova…

Index: Koldobskii; Vakhmistrov; Solodova; Shilova; Kalinin Doklady Chemistry, 2002 , vol. 387, # 1-3 p. 289 - 292

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Citation Number: 5

Abstract

2-Aryl-substituted cyclic imines and amines are important classes of biologically active compounds and are of great interest for biochemistry and medicine [1– 3]. The reported methods for the synthesis of similar compounds involve the cyclization of γ-amino ketones resulting from the catalytic hydrogenation of β- cyanoketones [4, 5] and the reaction of organolithium compounds with N-vinyl- or N-trimethylsilyl-substi- tuted lactams, followed by hydrolysis of the reaction mixtures [6, 7]. ...