Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments (1). Synthesis of 4-Hydroxyquinoline-. BETA.-glucosides

…, Y Wataya, HS Kim, I Tamai, M Kita, D Uemura

Index: Suzuki, Hiroshi; Aly, Nagwa S. M.; Wataya, Yusuke; Kim, Hye-Sook; Tamai, Ikumi; Kita, Masaki; Uemura, Daisuke Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 5 p. 821 - 824

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Citation Number: 7

Abstract

Malaria is one of the most serious infectious diseases in the developing world, with mortality estimated at ca. 2.5 mil- lion deaths annually, mainly caused by the erythrocytic-stage cells of Plasmodium falciparum.1) For four decades, malaria has been treated effectively with the 4-aminoquinoline ana- log chloroquine (CQ). However, CQ-resistant strains of Plas- modium spp. have spread and continue to evolve.1) Therefore, the development of new chemotherapeutic agents ...