Synthetic Communications

A shorter synthesis of muscimol

WM Welch

Index: Welch, W. M. Synthetic Communications, 1982 , vol. 12, # 14 p. 1089 - 1091

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Citation Number: 6

Abstract

Abstract The naturally occurring zwitterionic alkaloid muscimol 3 1 has been of considerable pharmacological interest in recent years, it being the best example of an in vivo active mimetic of the neurotransmitter γ-aminobutyric acid (GABA). 2 A number of syntheses of this compound have been reported over the past fourteen years, culminating in the recent report of Jager and Frey who prepared 1 in three steps and 30% overall yield. 3 These latter ...