Chemical communications

The use of a continuous flow-reactor employing a mixed hydrogen–liquid flow stream for the efficient reduction of imines to amines

S Saaby, KR Knudsen, M Ladlow, SV Ley

Index: Saaby, Steen; Knudsen, Kristian Rahbek; Ladlow, Mark; Ley, Steven V. Chemical Communications, 2005 , # 23 p. 2909 - 2911

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Citation Number: 64

Abstract

The ever-increasing number of potential therapeutic targets that are emerging from genomics and proteomics is driving the need to develop new synthetic technologies able to prepare small molecules as potential modulators. 1 In particular, flow processes, both on a microfluidic 2 and mesofluidic scale, 3 are receiving increased attention and offer a number of potential advantages over existing batch techniques. For example, reaction conditions (flow rate, stoichiometry, ...