The Journal of organic chemistry

Development of a Regioselective N-Methylation of (Benz) imidazoles Providing the More Sterically Hindered Isomer

E Van Den Berge, R Robiette

Index: Van Den Berge, Emilie; Robiette, Raphael Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12220 - 12223

Full Text: HTML

Citation Number: 4

Abstract

An efficient and highly regioselective N-methylation of (NH)-(benz) imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.