Halogenated flavanones as potential apoptosis-inducing agents: synthesis and biological activity evaluation

…, S Ajdari, J Davoodi, A Shafiee, A Foroumadi

Index: Safavi, Maliheh; Esmati, Nasim; Ardestani, Sussan Kabudanian; Emami, Saeed; Ajdari, Soheila; Davoodi, Jamshid; Shafiee, Abbas; Foroumadi, Alireza European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 573 - 580

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Citation Number: 20

Abstract

A series of halogenated flavanones were synthesized from 2-hydroxychalcones and tested for their cytotoxicity against a panel of human cancer cell lines. Among the synthesized compounds, 3′, 7-dichloroflavanone (2d) showed the highest activity against MCF-7, LNCaP, PC3, Hep-G2, KB and SK-N-MC cells. However, 3′, 6-dichloroflavanone (2g) with IC50 value of 2.9±0.9 μM was the most potent compound against MDA-MB-231 cells, ...