Journal of medicinal chemistry

Synthesis and anabolic activity of 3-methylene-and 3-methylsteroids of the androstane and 19-norandrostane series

K Irmscher, HG Kraft, K Brückner

Index: Irmscher,K. et al. J. Med. Chem., 1964 , vol. 7, p. 345 - 347

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Citation Number: 8

Abstract

The preparation of 3-methylene-l7~-methylandrostan-I7~-ol, its AI-and A4-derivatives, as well as the isomeric 3-methyl compounds, is described. Syntheses of several other 3- methyleneandrost-4-enes and 3-methylene-19-norandrost-4-enes are also reported. 3- Methylene-l7~-methylandrost-l-en-l7~-01 displays a high anabolic activity with a favorable anabolic-androgenic ratio.