A method for chemico-enzymatic synthesis of (2′-5′)-oligonucleotides with 6-N- benzylaminopurineriboside as the nucleoside units was proposed. The method consisted of enzymatic hydrolysis of the oligonucleotides with mixed (2′-5′)-(3′-5′)- phosphodiesterbonds that were prepared by polymerization of 6-N-benzyladenosine- 2′(3′)-monophosphate by using (3′-5′)-specific nuclease and phosphatase ...
