Canadian Journal of Chemistry

Prodigiosin synthesis with electron rich 2, 2'-bipyrroles

B Jolicoeur, WD Lubell

Index: Jolicoeur, Benoit; Lubell, William D. Canadian Journal of Chemistry, 2008 , vol. 86, # 3 p. 213 - 218

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Citation Number: 17

Abstract

The prodigiosins possess a linear tripyrrolic scaffold with the A and B pyrrolic rings connected directly in a bipyrrole unit, and the B and C rings joined in a dipyrrin. These red streptomycete metabolites exhibit among other activities, antitumor, antimicrobial, and immunomodulating properties. A new prodigiosin synthesis has been developed that employs electron rich 2, 2'-bipyrroles. In particular, undecylprodigiosin and PNU-156804 ...