Abstract: The asymmetric dipolar cycloaddition reaction of Me3SiCHN2 and auxiliary-bound methacrylate affords ready entry into optically active substituted pyrazolines. Herein we disclose an unusual alkaline fragmentation reaction of optically active pyrazoline 1 that affords an efficient synthesis of the pharmacologically important 2-methylaspartic acid in good yields. Additionally, in an alternative transformation of the pyrazoline (1), reductive ...
