New series of aryloxypropanolamines with both human β 3-adrenoceptor agonistic activity and free radical scavenging properties

S Aubriot, E Nicolle, M Lattier, C Morel, W Cao…

Index: Aubriot, Silvere; Nicolle, Edwige; Lattier, Mireille; Morel, Cecile; Cao, Wenhong; Daniel, Kiefer W.; Collins, Sheila; Leclerc, Gerard; Faure, Patrice Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 209 - 212

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Citation Number: 23

Abstract

A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β3-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl-or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl-or methoxyindolyl-type. Some of the ...