Synthesis of novel fluorinated bisphosphonates and bisphosphonic acids

…, RD Guneratne, AS Modak, DJ Burton

Index: Nair, Haridasan K.; Guneratne, Ranil D.; Modak, Anil S.; Burton, Donald J. Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2393 - 2398

Full Text: HTML

Citation Number: 29

Abstract

The synthesis of novel fluorinated bisphosphonates with two, three, four, and six difluoromethylene groups (la, lb, 8, 12, and 15)(44-78%) by different approaches is described. The bisphosphonates were converted to the corresponding trimethylsilyl esters which on treatment with deionized water afforded the respective bisphosphonic acids (6, 10, and 14) in good yields.