2-Oxo-1, 8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties

AA Santilli, AC Scotese, RF Bauer…

Index: Santilli, Arthur A.; Scotese, Anthony C.; Bauer, Raymond F.; Bell, Stanley C. Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2270 - 2277

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Citation Number: 55

Abstract

The syntheses of 2-oxo-l, 8-naphthyridine-3-carboxylic acid derivatives having potent gastric antisecretory properties in the pyloric-ligated (Shay) rat model are described. Two of the more potent compounds tested that were selected for more detailed dose-response evaluation were 4-amino-l-ethyl-l, 2-dihydro-2-oxonaphthyridine-3-carboxylic acid ethyl ester (35) and l-ethyl-1, 2-dihydro-7-methyl-4-(4-methyl-l-piperazinyl)-2-oxo-l, 8- ...