Scaffold-switching: An exploration of 5, 6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo [1, 2-a] pyridine-3-carboxylates

…, AG Oliver, LD Markley, S Cho, SG Franzblau…

Index: Moraski, Garrett C.; Oliver, Allen G.; Markley, Lowell D.; Cho, Sanghyun; Franzblau, Scott G.; Miller, Marvin J. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 15 p. 3493 - 3498

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Citation Number: 9

Abstract

Abstract A set of 5, 6-fused bicyclic heteroaromatic scaffolds were investigated for their in vitro anti-tubercular activity versus replicating and non-replicating strains of Mycobacterium tuberculosis (Mtb) in an attempt to find an alternative scaffold to the imidazo [1, 2-a] pyridine and imidazo [1, 2-a] pyrimidines that were previously shown to have potent activity against replicating and drug resistant Mtb. The five new bicyclic heteroaromatic scaffolds explored ...