Selective palladium-catalyzed arylation of ammonia: Synthesis of anilines as well as symmetrical and unsymmetrical di-and triarylamines

DS Surry, SL Buchwald

Index: Surry, David S.; Buchwald, Stephen L. Journal of the American Chemical Society, 2007 , vol. 129, # 34 p. 10354 - 10355

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Citation Number: 211

Abstract

It is shown that by selection of an appropriate palladium/ligand system, temperature, concentration, and stoichiometry of reagents, ammonia may be selectively arylated to give either anilines, symmetrical di-, or triarylamines. Furthermore different aryl halides may be added sequentially to the reaction mixture, allowing the synthesis of unsymmetrical di-and triarylamines from aryl halides and ammonia in a one-pot protocol