Mass spectrometry of nucleic acid constituents. Trimethylsilyl derivatives of nucleosides

H Pang, KH Schram, DL Smith, SP Gupta…

Index: Pang, Henrianna; Schram, Karl H.; Smith, David L.; Gupta, S.P.; Townsend, Leroy B.; McCloskey, James A. Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3923 - 3932

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Citation Number: 70

Abstract

Trimethylsilylation of nucleosides provides derivatives which are thermally volatile and whose electron-ionization mass spectra are useful for structural characterization and for determination of chemically or biologically incorporated stable isotopes. The major reaction pathways and mechanisms of fragmentation of silylated nucleosides have been studied, on the basis of the mass spectra of a structural variety of nucleoside analogues and of uridine ...