The Journal of Organic Chemistry

Pyrrole chemistry. An improved synthesis of ethyl pyrrole-2-carboxylate esters from diethyl aminomalonate

JB Paine III, D Dolphin

Index: Paine, John B.; Dolphin, David Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5598 - 5604

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Citation Number: 65

Abstract

Ethyl pyrrole-2-carboxylates, versatile precursors for the total synthesis of both synthetic model and naturally occurring tetrapyrroles and porphyrins, can be prepared in greatly improved yields by the addition of 1, 3-diketones and preformed diethyl aminomalonate to boiling glacial acetic acid. The method is suitable for both small-and large-scale synthesis and has proved far more reliable than the original in situ dissolving zinc reduction of ...