Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers

ST McCracken, M Kaiser, HI Boshoff, PDW Boyd…

Index: McCracken, Stephen T.; Kaiser, Marcel; Boshoff, Helena I.; Boyd, Peter D.W.; Copp, Brent R. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 4 p. 1482 - 1493

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Citation Number: 18

Abstract

Previous studies have identified the 3, 6-dialkyl-4-hydroxy-pyran-2-one marine microbial metabolites pseudopyronines A and B to be modest growth inhibitors of Mycobacterium tuberculosis and a range of tropical diseases including Plasmodium falciparum and Leishmania donovani. In an effort to expand the structure–activity relationship of this compound class towards infectious diseases, a library of natural product and natural ...